Central nervous system toxicity (coma andĬonvulsions) may also occur because of its high Propranolol decreases sinus rate, atrio-ventricularĬonduction, intraventricular conduction and cardiacĬontractility. The cardiovascular system is the main target organ. Membrane stabilizing properties and is highly lipid soluble.Īt toxic doses, propranolol has a pronounced negativeĬhronotropic and inotropic effect and also a quinidine-like Propranolol is not cardioselectiveĪnd it has no intrinsic sympathomimetic activity. SUMMARY 2.1 Main risks and target organs Beta-blockers compete with endogenous and/or exogenousīeta-adrenergic agonists. 1.6 Manufacturers, Importers No data available.
Sumial (Spain) Tensiflex (Argentina) Teenol (Japan) Tonum Rexigen (South Africa) Sagittol (Germany) Sawatal (Japan) Pur bloka (South Africa) Pylapron (Japan) Reducor (Turkey) (Argentina) Propanur (Germany) Propra-ratiopharm (Germany) Pronovan (Norway) Propabloc (Germany) Propalong Pranolol (Norway) Prano-puren (Germany) Prolol (Australia) Novopralol (Canada) Obsidan (Germany) Oposim (Argentina) Kemi (Japan) Nedis (Argentina) Noloten (Argentina) States of America) Inderalici (Italy) Indobloc (Germany) South Africa Sweden Switzerland United Kingdom United (Japan) Ikopal (Iceland) Indéral (Argentina Australia īelgium Canada Denmark Italy, Japan Nether Lands Norway
(Japan) Corotrend (Switzerland) Deralin (Australia,Israel) ĭetensol (Canada) Dideral (Turkey) Dociton (Germany) Įfektolol (Germany) Elbrol (Germany) Euprovasin (Italy) įrekven (Denmark Norway Sweden) Herzbase (Japan) Herzul (France) Beta-tablinen (Germany) Blocardyl (Argentina) Ĭardinol (Australia) Cadispare (South Africa) Caridolol (Austria) Apsolol (United Kingdom) Avlocrdyl (France) īedranol (Switzerland - United Kingdom) Beprane (France) īerkolol (United Kingdom) Beta-Neg (Italy) Betaryl NAME 1.1 Substance Propranolol 1.2 Group Beta-blocker Beta-adrenergic receptor blocking agent Class II antiarrhythmic drug 1.3 Synonyms 1-isopropylamine-3-(1-naphtylhoxy)-2 propanol ġ-isopropylamine-3-(alpha naphthoxy)-2 propanol-hydrochloride ġ-isopropylamino-3-(1-naphthyloxy)propan-2-ol ġ-isopropylamino-3-(1-naphthyloxy)propan-2-olhydrochloride ġ.4 Identification numbers 1.4.1 CAS numberģ18-98-9 AY - 64043 ICI - 45520 NCS - 91523 RTECS: UB 7500000 propranolol base RTECS: UB 7525000 propranolol hydrochloride 1.5 Main brand names, main trade names Angilol (United Kingdom) Arcablock-Retard-Capsules International Programme on Chemical Safetyġ. AUTHOR(S), REVIEWER(S), DATE(S) (INCLUDING UPDATES), COMPLETE ADDRESS(ES) TOXICOLOGICAL ANALYSES AND BIOMEDICAL INVESTIGATIONSĨ.1.2 Storage of laboratory samples and specimensĨ.1.3 Transport of laboratory samples and specimensĨ.2 Toxicological analyses and their interpretationĨ.2.1 Tests on toxic ingredient(s) of materialĨ.2.1.2 Advanced qualitative confirmation test(s)Ĩ.2.2.2 Advanced qualitative confirmation test(s)Ĩ.2.3 Interpretation of toxicological analysesĨ.3 Biomedical investigations and their interpretationĨ.3.4 Interpretation of biomedical investigationsĨ.4 Other biomedical (diagnostic) investigations and their interpretationĨ.5 Overall Interpretation of all toxicological analyses and toxicological investigationsĩ.4 Systematic description of clinical effectsĩ.4.9 Eye, ear, nose, throat: local effectsĩ.4.12.2 Fluid and electrolyte disturbancesġ0.2 Life supportive procedures and symptomatic/specific treatmentġ4. NAMEĢ.4 First aid measures and management principlesĦ.3 Biological half-life by route of exposureĨ.
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